EAN (EXPERIMENTAL ALLERGIC NEURITIS)
\ˌiːˌe͡ɪˈɛn ɛkspˌɛɹɪmˈɛntə͡l ɐlˈɜːd͡ʒɪk njuːɹˈa͡ɪtɪs], \ˌiːˌeɪˈɛn ɛkspˌɛɹɪmˈɛntəl ɐlˈɜːdʒɪk njuːɹˈaɪtɪs], \ˌiː__ˌeɪ_ˈɛ_n__ ɛ_k_s_p_ˌɛ_ɹ_ɪ_m_ˈɛ_n_t_əl ɐ_l_ˈɜː_dʒ_ɪ_k n_j_uː_ɹ_ˈaɪ_t_ɪ_s]\
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An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84 (1):40-52)
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Platidiam
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Nearby Words
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