PAGANO'S REACTION
\paɡˈɑːnə͡ʊz ɹɪˈakʃən], \paɡˈɑːnəʊz ɹɪˈakʃən], \p_a_ɡ_ˈɑː_n_əʊ_z ɹ_ɪ__ˈa_k_ʃ_ə_n]\
Definitions of PAGANO'S REACTION
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.