CADASILS
\kˈadasə͡lz], \kˈadasəlz], \k_ˈa_d_a_s_əl_z]\
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Loss of higher cortical functions with retained awareness due to multiple cortical or subcortical CEREBRAL INFARCTION. Memory, judgement, attention span, and impulse control are often impaired, and may be accompanied by PSEUDOBULBAR PALSY, hemiparesis, reflex abnormalities, and other signs of localized neurologic dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p1060)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.