CR4 RECEPTOR
\sˌiːˈɑː fˈɔː ɹɪsˈɛptə], \sˌiːˈɑː fˈɔː ɹɪsˈɛptə], \s_ˌiː__ˈɑː f_ˈɔː ɹ_ɪ_s_ˈɛ_p_t_ə]\
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A major adhesion-associated heterodimer molecule expressed by human monocytes, granulocytes, NK cells, and some lymphocytes. The alpha subunit is the CD11c antigen (also called Leu-M5), a surface antigen expressed on some myeloid cells. The beta subunit is the CD18 antigen (ANTIGENS, CD18). The complement 4-binding protein has been shown to play an important role in cell-cell and cell-substrate adhesive interactions.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.