GRANCHER'S TRIAD, HUTCHINSON'S TRIAD

\ɡɹˈant͡ʃəz tɹˈa͡ɪad], \ɡɹˈant‍ʃəz tɹˈa‍ɪad], \ɡ_ɹ_ˈa_n_tʃ_ə_z t_ɹ_ˈaɪ__a_d]\

Definitions of GRANCHER'S TRIAD, HUTCHINSON'S TRIAD

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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