HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA
\hɪɹˈɛdɪtəɹi ˌɔːtə͡ʊsˈə͡ʊmə͡l dˈɒmɪnənt spˈastɪk pˌaɹəplˈiːd͡ʒə], \hɪɹˈɛdɪtəɹi ˌɔːtəʊsˈəʊməl dˈɒmɪnənt spˈastɪk pˌaɹəplˈiːdʒə], \h_ɪ_ɹ_ˈɛ_d_ɪ_t_ə_ɹ_i_ ˌɔː_t_əʊ_s_ˈəʊ_m_əl d_ˈɒ_m_ɪ_n_ə_n_t s_p_ˈa_s_t_ɪ_k p_ˌa_ɹ_ə_p_l_ˈiː_dʒ_ə]\
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A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progessive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64 (1):61-6; Curr Opin Neurol 1997 Aug;10 (4):313-8)
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Word of the day
basidiomycota
- comprises fungi bearing the spores on basidium: Gasteromycetes (puffballs); Tiliomycetes (comprising orders Ustilaginales (smuts) and Uredinales (rusts)); Hymenomycetes (mushrooms; toadstools; agarics; bracket fungi); in some classification systems considered a division of kingdom comprises fungi bearing spores on a basidium; includes Gasteromycetes (puffballs) Tiliomycetes comprising the orders Ustilaginales (smuts) and Uredinales (rusts) Hymenomycetes (mushrooms, toadstools, agarics bracket fungi).
Nearby Words
- hereditary
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- hereditary amyloidosis
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- hereditary ataxias
- Hereditary Autosomal Dominant Spastic Paraplegia
- hereditary autosomal recessive spastic paraplegia
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- hereditary central nervous system demyelinating diseases
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