MDX MOUSE
\ˌɛmdˌiːˈɛks mˈa͡ʊs], \ˌɛmdˌiːˈɛks mˈaʊs], \ˌɛ_m_d_ˌiː__ˈɛ_k_s m_ˈaʊ_s]\
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A strain of mice arising from a spontaneous mutation (mdx) in inbred C57BL mice. This mutation is X chromosome-linked and produces viable homozygous animals that lack the muscle protein dystrophin, have high serum levels of muscle enzymes, and possess histological lesions similar to human muscular dystrophy. The histological features, linkage, and map position of mdx make these mice a worthy animal model of Duchenne muscular dystrophy.
By DataStellar Co., Ltd
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.