NATIONAL ACADEMY OF SCIENCES (U.S.)

\nˈaʃənə͡l ɐkˈadəmi ɒv sˈa͡ɪ͡ənsɪz jˌuːˈɛs], \nˈaʃənə‍l ɐkˈadəmi ɒv sˈa‍ɪ‍ənsɪz jˌuːˈɛs], \n_ˈa_ʃ_ə_n_əl ɐ_k_ˈa_d_ə_m_i_ ɒ_v s_ˈaɪə_n_s_ɪ_z__ j_ˌuː_ˈɛ_s]\

Definitions of NATIONAL ACADEMY OF SCIENCES (U.S.)

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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