PYRUVIC DECARBOXYLASE
\pa͡ɪɹˈuːvɪk dɪkˈɑːbəksˌɪle͡ɪs], \paɪɹˈuːvɪk dɪkˈɑːbəksˌɪleɪs], \p_aɪ_ɹ_ˈuː_v_ɪ_k d_ɪ_k_ˈɑː_b_ə_k_s_ˌɪ_l_eɪ_s]\
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Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.