UNDESPONDENT
\ˌʌndɪspˈɒndənt], \ˌʌndɪspˈɒndənt], \ˌʌ_n_d_ɪ_s_p_ˈɒ_n_d_ə_n_t]\
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un-des-pon'dent, adj. not despondent.--adv. UNDESPOND'ENTLY.
By Thomas Davidson
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.