MALADIE NOIRE

\mˈale͡ɪdi nwˈɑː], \mˈale‍ɪdi nwˈɑː], \m_ˈa_l_eɪ_d_i n_w_ˈɑː]\
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  • Melaena -m. du Pays, Nostalgia- m. Pediculaire, Phtheiriasis- m. de Pott, Vertebral disease-m. Typhoide, see Typhus-m. Venerienne, Syphilis-m. de Venus, Syphilis- m. de Werlhof, Purpura haemorrhagica.
1846 - Medical lexicon: a dictionary of medical science
By Robley Dunglison

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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